tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate

Base Information

Chemical Name:tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate
CAS No.:1217299-26-7
Molecular Formula:C₁₈H₁₉FN₄O₄
Molecular Weight:374.372
Hs Code.:

Synonyms:tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate

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Chemical Property of tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate

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Technology Process of tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate

There total 5 articles about tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1217299-25-6
tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate

: 1217299-26-7
tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate

Guidance literature:: With pyridine; In tetrahydrofuran; at 0 - 20 ℃; Reflux;
DOI:10.1021/jm900607f

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1217299-26-7
tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: indium(III) chloride / 2 h / 35 °C / Neat (no solvent)

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 50 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / H-Cube apparatus

4.1: pyridine / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

With pyridine; hydrogen; sodium hydride; indium(III) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide; mineral oil;

Reference yield:

: 911297-02-4
N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

: 1217299-26-7
tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 2 h / 50 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / H-Cube apparatus

3.1: pyridine / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

With pyridine; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide; mineral oil;