tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate

Base Information

Chemical Name:tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate
CAS No.:1217299-25-6
Molecular Formula:C₁₇H₂₁FN₄O₃
Molecular Weight:348.377
Hs Code.:

Synonyms:tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate

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Chemical Property of tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate

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Technology Process of tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate

There total 3 articles about tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1217299-25-6
tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: indium(III) chloride / 2 h / 35 °C / Neat (no solvent)

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 50 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / H-Cube apparatus

With hydrogen; sodium hydride; indium(III) chloride; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; mineral oil;

Reference yield:

: 911297-02-4
N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

: 1217299-25-6
tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 2 h / 50 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / H-Cube apparatus

With hydrogen; sodium hydride; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; mineral oil;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1217299-25-6
tert-butyl 4-(3-amino-2-(methylamino)pyridin-4-yloxy)-2-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: indium(III) chloride / 2 h / 35 °C / Neat (no solvent)

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 50 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / H-Cube apparatus

With hydrogen; sodium hydride; indium(III) chloride; palladium 10% on activated carbon; In ethanol; dimethyl sulfoxide; mineral oil;