2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate

Base Information

Chemical Name:2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate
CAS No.:1279101-06-2
Molecular Formula:C₁₈H₁₄Cl₂FNO₅
Molecular Weight:414.217
Hs Code.:

Synonyms:2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate

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Chemical Property of 2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate

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Technology Process of 2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate

There total 8 articles about 2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1279100-97-8
2-bromoethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate

: 1279101-06-2
2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: With silver nitrate; In acetonitrile; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/jm101450p

Reference yield:

: 499983-13-0
2-( 4-bromo-3-fluorophenyl)acetonitrile

: 1279101-06-2
2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 4 h / 25 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 8 h / 100 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 120 °C / Inert atmosphere

4.1: oxalyl dichloride / dichloromethane / 5 h / 25 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / Inert atmosphere

6.1: silver nitrate / acetonitrile / 2 h / Inert atmosphere; Reflux

With oxalyl dichloride; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; silver nitrate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; toluene; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1021/jm101450p

Reference yield:

: 127425-73-4
1-bromo-4-(bromomethyl)-2-fluorobenzene

: 1279101-06-2
2-(nitrooxy)ethyl 1-(3',4'-dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 2 h / 80 °C / Inert atmosphere

2.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 4 h / 25 °C / Inert atmosphere

3.1: sodium hydroxide / methanol / 8 h / 100 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: tetrabutylammomium bromide; palladium diacetate; sodium carbonate / water / 120 °C / Inert atmosphere

5.1: oxalyl dichloride / dichloromethane / 5 h / 25 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / Inert atmosphere

7.1: silver nitrate / acetonitrile / 2 h / Inert atmosphere; Reflux

With oxalyl dichloride; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; silver nitrate; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane; water; toluene; acetonitrile; 4.1: Suzuki coupling;
DOI:10.1021/jm101450p