1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carboxylic acid

Base Information

Chemical Name:1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carboxylic acid
CAS No.:749269-74-7
Molecular Formula:C10H8BrFO2
Molecular Weight:259.075
Hs Code.:2916399090
European Community (EC) Number:813-370-0
DSSTox Substance ID:DTXSID30470055
Wikidata:Q82298021
Mol file:749269-74-7.mol

Synonyms:749269-74-7;1-(4-Bromo-3-fluorophenyl)cyclopropanecarboxylic acid;1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carboxylic acid;MFCD19692953;SCHEMBL1118018;DTXSID30470055;WKVFGGQPVGDERD-UHFFFAOYSA-N;ZEB26974;AKOS023469821;SB17760;AS-51435;SY226363;CS-0054518;FT-0699432;P12671;4-bromo-3-fluorophenylcyclopropanecarboxylic acid;EN300-1915729;A865769;1-(4-Bromo-3-fluorophenyl)cyclopropanecarboxylicacid;1-(4-bromo-3-fluoro-phenyl)-cyclopropanecarboxylic acid

Suppliers and Price of 1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(4-Bromo-3-fluorophenyl)cyclopropanecarboxylicacid 95+%
250mg
$ 162.00

Crysdot
1-(4-Bromo-3-fluorophenyl)cyclopropanecarboxylicacid 95+%
1g
$ 406.00

Chemenu
1-(4-Bromo-3-fluorophenyl)cyclopropanecarboxylicacid 95%
1g
$ 380.00

Alichem
1-(4-Bromo-3-fluorophenyl)cyclopropanecarboxylicacid
1g
$ 357.52

AK Scientific
1-(4-Bromo-3-fluorophenyl)cyclopropanecarboxylicacid
1g
$ 1032.00

Total 10 raw suppliers

Chemical Property of 1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carboxylic acid

Chemical Property:

PSA：37.30000
LogP:2.70440
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:257.96917
Heavy Atom Count:14
Complexity:253

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Bromo-3-fluorophenyl)cyclopropanecarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1(C2=CC(=C(C=C2)Br)F)C(=O)O

Technology Process of 1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carboxylic acid

There total 7 articles about 1-(4-Bromo-3-fluorophenyl)cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 749269-73-6
1-(4-bromo-3-fluorophenyl)cyclopropane-1-carbonitrile

: 749269-74-7
1-(4-bromo-3-fluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 100 ℃; for 8h;
DOI:10.1021/jm0502541

Reference yield:

: 499983-13-0
2-( 4-bromo-3-fluorophenyl)acetonitrile

: 749269-74-7
1-(4-bromo-3-fluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / aq. NaOH; tetrabutylammonium bromide / toluene / 4 h / 20 °C

2: 76 percent / aq. NaOH / methanol / 8 h / 100 °C

With sodium hydroxide; tetrabutylammomium bromide; In methanol; toluene;
DOI:10.1021/jm0502541

Reference yield:

: 127425-73-4
1-bromo-4-(bromomethyl)-2-fluorobenzene

: 749269-74-7
1-(4-bromo-3-fluorophenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 5 g / ethanol / 2 h / 80 °C

2: 91 percent / aq. NaOH; tetrabutylammonium bromide / toluene / 4 h / 20 °C

3: 76 percent / aq. NaOH / methanol / 8 h / 100 °C

With sodium hydroxide; tetrabutylammomium bromide; In methanol; ethanol; toluene;
DOI:10.1021/jm0502541