3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate

Base Information

Chemical Name:3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate
CAS No.:870678-56-1
Molecular Formula:C₂₀H₁₇FN₂O₅S
Molecular Weight:416.43
Hs Code.:

Synonyms:3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate

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Chemical Property of 3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate

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Technology Process of 3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate

There total 5 articles about 3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 602312-26-5
6-amino-5-(4-fluorobenzoyl)-1-[3-(hydroxymethyl)phenyl]pyridin-2(1H)-one

: 124-63-0
methanesulfonyl chloride

: 870678-56-1
3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.916667h;
DOI:10.1021/jo0515428

Reference yield:

: 870678-48-1
(2E)-3-amino-3-[(4-chlorophenyl)thio]-1-(4-fluorophenyl)prop-2-en-1-one

: 870678-56-1
3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / acetic acid / 2 h / Heating

2: 52 percent / methanol / Heating

3: 89 percent / triethylamine / CH₂Cl₂ / 0.92 h / 0 - 20 °C

With acetic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo0515428

Reference yield:

: 870678-12-9
(E)-3-Amino-1-(4-fluoro-phenyl)-3-(3-hydroxymethyl-phenylamino)-propenone

: 870678-56-1
3-[6-amino-5-(4-fluorobenzoyl)-2-oxopyridin-1(2H)-yl]benzyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / methanol / Heating

2: 89 percent / triethylamine / CH₂Cl₂ / 0.92 h / 0 - 20 °C

With triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo0515428