(R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE

Base Information

Chemical Name:(R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE
CAS No.:958329-37-8
Molecular Formula:C₂₅H₂₇FN₂O₃S
Molecular Weight:454.565
Hs Code.:

Synonyms:(R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE

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Chemical Property of (R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE

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Technology Process of (R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE

There total 4 articles about (R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 6-(1-methylcyclopropyl)-2-naphthoic acid

: 958331-24-3
N-{4-[(1R)-1-aminoethyl]-5-fluoro-2-methylphenyl}methanesulfonamide hydrochloride

: 958329-37-8
(R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 33627-00-8
methyl 6-acetyl-2-naphthoate

: 958329-37-8
(R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

1.2: 2 h / 20 °C

2.1: diethylzinc / hexane; 1,2-dichloro-ethane / 20 h / 60 °C

3.1: sodium hydroxide; water / methanol / 2 h / 60 °C

3.2: pH < 3

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

With potassium tert-butylate; water; diethylzinc; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 958332-47-3
methyl 6-isopropenyl-2-naphthoate

: 958329-37-8
(R)-N-(1-(2-FLUORO-5-METHYL-4-(METHYLSULFONAMIDO)PHENYL)ETHYL)-6-(1-METHYL-CYCLOPROPYL)-2-NAPHTHAMIDE

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethylzinc / hexane; 1,2-dichloro-ethane / 20 h / 60 °C

2.1: sodium hydroxide; water / methanol / 2 h / 60 °C

2.2: pH < 3

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C

With water; diethylzinc; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In methanol; hexane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;