(E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate

Base Information

Chemical Name:(E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate
CAS No.:1402823-95-3
Molecular Formula:C₂₀H₂₇ClN₂O₄
Molecular Weight:394.898
Hs Code.:

Synonyms:(E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate

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Technology Process of (E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate

There total 3 articles about (E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 127604-92-6,132145-65-4
dimethyl 2-(4-chlorophenyl)cyclopropane-1,1-dicarboxylate

: 693-13-0
diisopropyl-carbodiimide

: 1402823-95-3
(E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate

Guidance literature:: With tin(II) trifluoromethanesulfonate; In dichloromethane; at 23 ℃; for 6h; stereospecific reaction; Inert atmosphere; Glovebox;
DOI:10.1021/ol302494n DOI:10.1021/ol302494n

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 1402823-95-3
(E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Rh₂(esp)2 / dichloromethane / 0 - 22 °C / Inert atmosphere

1.2: 12 h / 60 °C

2.1: tin(II) trifluoromethanesulfonate / dichloromethane / 6 h / 23 °C / Inert atmosphere; Glovebox

With tin(II) trifluoromethanesulfonate; In dichloromethane;
DOI:10.1021/ol302494n DOI:10.1021/ol302494n

Reference yield:

: 6773-29-1
dimethyl diazomalonate

: 1402823-95-3
(E)-dimethyl 5-(4-chlorophenyl)-1-isopropyl-2-(isopropylimino)pyrrolidine-3,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Rh₂(esp)2 / dichloromethane / 0 - 22 °C / Inert atmosphere

1.2: 12 h / 60 °C

2.1: tin(II) trifluoromethanesulfonate / dichloromethane / 6 h / 23 °C / Inert atmosphere; Glovebox

With tin(II) trifluoromethanesulfonate; In dichloromethane;
DOI:10.1021/ol302494n DOI:10.1021/ol302494n