(R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate

Base Information

Chemical Name:(R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate
CAS No.:1300730-12-4
Molecular Formula:C₂₃H₂₂N₄O₄
Molecular Weight:418.452
Hs Code.:

Synonyms:(R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate

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Chemical Property of (R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate

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Technology Process of (R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate

There total 4 articles about (R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₄H₄₀N₄O₆

: 1300730-12-4
(R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate

Guidance literature:: C₄₄H₄₀N₄O₆; With acetic acid; In methanol; at 20 ℃; for 0.5h;

With potassium carbonate; In methanol; pH=8 - 9;

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1300730-13-5
C₃₀H₂₆N₂O₃

: 188067-60-9
(R)-methyl 2-amino-3-(1-methyl-1H-indol-3-yl)propanoate

: 1300730-12-4
(R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate

Guidance literature:: bis(trichloromethyl) carbonate; (R)-methyl 2-amino-3-(1-methyl-1H-indol-3-yl)propanoate; With triethylamine; In dichloromethane; at 0 ℃; for 1h;

C₃₀H₂₆N₂O₃; With dmap; In dichloromethane; at 20 ℃;

Reference yield:

: 19170-74-2
2-(1H-imidazole-4-yl)phenol

: 1300730-12-4
(R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 °C

2.2: 20 °C

3.1: acetic acid / methanol / 0.5 h / 20 °C

3.2: pH 8 - 9

With acetic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;