2-(1H-Imidazol-4-yl)phenol

Base Information

• Chemical Name: 2-(1H-Imidazol-4-yl)phenol
• CAS No.: 19170-74-2
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.175
• UNII: CJ4E5VXN2Z
• ChEMBL ID: CHEMBL457063
• Mol file: 19170-74-2.mol

Synonyms:2-(1H-Imidazol-4-yl)phenol;2-(1H-Imidazol-5-yl)-phenol;19170-74-2;2-(1H-Imidazol-5-yl)phenol;CJ4E5VXN2Z;Phenol, 2-(1H-imidazol-4-yl)-;Phenol, 2-(1H-imidazol-5-yl)-;UNII-CJ4E5VXN2Z;D0NI8W;CHEMBL457063;SCHEMBL1502109;BDBM24663;2-(1H-imidazol-4-yl)phenol, 1;AKOS006288294;AB93320;PD179672;CS-0228684;F78890;EN300-1837818

Chemical Property of 2-(1H-Imidazol-4-yl)phenol

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

99% ^*data from raw suppliers

2-(1H-IMIDAZOL-4-YL)-PHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=CN=CN2)O

Technology Process of 2-(1H-Imidazol-4-yl)phenol

There total 3 articles about 2-(1H-Imidazol-4-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 2-(2-bromoacetyl)hydroxybenzene (2491-36-3) → 2-(1H-imidazole-4-yl)phenol (19170-74-2)

Guidance literature:

at 170 - 180 ℃;

DOI:10.1021/acs.jmedchem.0c01968

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-hydroxy-1-(2-hydroxyphenyl)ethanone (17375-96-1) → 2-(1H-imidazole-4-yl)phenol (19170-74-2)

Guidance literature:

With ammonium hydroxide; copper diacetate;

Reference yield:

→ 2-(1H-imidazole-4-yl)phenol (19170-74-2)

Guidance literature:

Formamid, 2-Brom-2'-hydroxyacetophenon;

DOI:10.1021/ja00754a051

upstream raw materials:

formaldehyd

2-hydroxy-1-(2-hydroxyphenyl)ethanone

formamide

2-(2-bromoacetyl)hydroxybenzene

Downstream raw materials:

1-acetoxy-2-(1⁽³⁾H-imidazol-4-yl)-benzene

C₃₀H₂₆N₂O₃

(R)-methyl 2-(((2-(1H-imidazol-4-yl)phenoxy)carbonyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoate

2-(1-trityl-1H-imidazol-4-yl)phenol