N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine

Base Information

Chemical Name:N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine
CAS No.:86954-41-8
Molecular Formula:C₂₂H₂₉N₅O₇
Molecular Weight:475.502
Hs Code.:

Synonyms:N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine

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Chemical Property of N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine

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Technology Process of N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine

There total 4 articles about N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 108-91-8,157973-60-9
cyclohexylamine

: 78586-33-1
4-chloro-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidine

: 86954-41-8
N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine

Guidance literature:: In dichloromethane; for 24h; Ambient temperature;
DOI:10.1021/jm00365a010

Reference yield:

: 51642-61-6
1-(trimethylsilyl)-4-(trimethylsilyloxy)-1H-pyrazolo<3,4-d>pyrimidine

: 86954-41-8
N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / BF₃*OEt₂ / dioxane / 0.5 h / Heating

2: 51 percent / thionyl chloride, N,N-diethylaniline / CHCl₃; dimethylformamide / 4 h / Heating

3: 99 percent / CH₂Cl₂ / 24 h / Ambient temperature

With thionyl chloride; boron trifluoride diethyl etherate; N,N-diethylaniline; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00365a010

Reference yield:

: 315-30-0
Allopurinol

: 86954-41-8
N-cyclohexyl-1-(2,3,5-tri-O-acetyl-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / ammonium sulfate / 14 h / Heating

2: 38 percent / BF₃*OEt₂ / dioxane / 0.5 h / Heating

3: 51 percent / thionyl chloride, N,N-diethylaniline / CHCl₃; dimethylformamide / 4 h / Heating

4: 99 percent / CH₂Cl₂ / 24 h / Ambient temperature

With ammonium sulfate; thionyl chloride; boron trifluoride diethyl etherate; N,N-diethylaniline; In 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00365a010