(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate

Base Information

• Chemical Name: (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate
• CAS No.: 752174-62-2
• Molecular Formula: C₂₀H₂₅NO₂
• Molecular Weight: 311.424
• Mol file: 752174-62-2.mol

Synonyms:(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester

Chemical Property of (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate

Chemical Property:

Purity/Quality:

99.5% ^*data from raw suppliers

(2R,4S)-Ethyl5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate

There total 38 articles about (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethanol (64-17-5) + (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid (1039307-95-3) → (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester (752174-62-2,753421-85-1)

Guidance literature:

With thionyl chloride; at 40 - 70 ℃;

Reference yield: 90.1%

(R)-5-([1,1`-biphenyl]-4-yl)-2-methyl-4-pentanone ethyl ester → (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester (752174-62-2,753421-85-1)

Guidance literature:

With hydrogenchloride; tris(hydroxymethyl)aminomethyl-hydrochloric acid; pyridoxal 5'-phosphate; isopropylamine; In water; dimethyl sulfoxide; at 35 - 40 ℃; for 24h; pH=7.5 - 8.0;

Reference yield: 88.0%

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid (1012341-50-2,1012341-54-6) + ethanol (64-17-5) → (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester (752174-62-2,753421-85-1)

Guidance literature:

With thionyl chloride; at 78 ℃; Temperature;

upstream raw materials:

methyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutyrate

4-biphenylacetonitrile

ethanol

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride

Downstream raw materials:

α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methyl pentanoate

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one