3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride

Base Information

• Chemical Name: 3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride
• CAS No.: 340127-55-1
• Molecular Formula: C₁₉H₃₃ClO₃Si₂
• Molecular Weight: 401.093
• Mol file: 340127-55-1.mol

Synonyms:3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride

Chemical Property of 3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride

There total 4 articles about 3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,5-bis(tert-butyldimethylsilyloxy)benzoic acid tert-butyldimethylsilyl ester (331720-33-3) → 3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride (340127-55-1)

Guidance literature:

With oxalyl dichloride; benzyltrimethylammonium chloride; In dichloromethane; for 18h; Heating;

DOI:10.1021/ma021232g

Reference yield:

3,5-bis-(tert-butyldimethylsilanyloxy)-benzoic acid (158139-68-5) → 3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride (340127-55-1)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/j.bmc.2013.07.037

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 3,5-bis(tert-butyldimethylsilyl)oxybenzoyl chloride (340127-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / toluene / 18 h / Reflux; Inert atmosphere

1.2: 12 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; toluene;

upstream raw materials:

3,5-bis-(tert-butyldimethylsilanyloxy)-benzoic acid

3,5-bis(tert-butyldimethylsilyloxy)benzoic acid tert-butyldimethylsilyl ester

tert-butyldimethylsilyl chloride

3,5-Dihydroxybenzoic acid

Downstream raw materials:

((5-bromo-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

3,5-dihydroxy-N-(naphthalen-2-yl)benzamide

(6-butoxy-3',5'-bis-(3-butoxy-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-biphenyl-4-yl)-methanol

4-bromomethyl-6-butoxy-3',5'-bis-(3-butoxy-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-biphenyl

Refernces

• 1、 -. "Tumor diagnosis and treatment fluorescent probe for targeting tumor Wolburg effect". Paragraph 0129-0131; 0134-0135. . Retrieved 2020/11/02.
• 2、 Lambrych, Kevin R.,Gitsov, Ivan. "Linear-dendritic poly(ester)-block-poly(ether)-block-poly(ester) ABA copolymers constructed by a divergent growth method". . p. 1068 - 1074. Retrieved 2007/10/03.