6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Base Information

• Chemical Name: 6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
• CAS No.: 262433-34-1
• Molecular Formula: C₂₃H₂₁BrN₄O
• Molecular Weight: 449.35
• Mol file: 262433-34-1.mol

Synonyms:6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Chemical Property of 6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

There total 2 articles about 6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Lck Inhibitor (213743-31-8) → 6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (262433-34-1)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/S0960-894X(00)00442-X

Reference yield:

→ 6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (262433-34-1)

Guidance literature:

Reference yield: 95.0%

tri-n-butyl(vinyl)tin (7486-35-3) + 6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (262433-34-1) → 7-cyclopentyl-5-(4-phenoxy-phenyl)-6-vinyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 18h;

DOI:10.1016/S0960-894X(00)00442-X

upstream raw materials:

Lck Inhibitor

Downstream raw materials:

4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile