4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile

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Chemical Name:4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile
CAS No.:262431-64-1
Molecular Formula:C₂₄H₂₁N₅O
Molecular Weight:395.464
Hs Code.:

Synonyms:4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile

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Chemical Property of 4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile

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Technology Process of 4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile

There total 3 articles about 4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 557-21-1
dicyanozinc

: 262433-34-1
6-bromo-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

: 262431-64-1
4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; In 1-methyl-pyrrolidin-2-one; at 90 ℃; for 18h;
DOI:10.1016/S0960-894X(00)00442-X

Reference yield:

: 213743-31-8
Lck Inhibitor

: 262431-64-1
4-amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo-[2,3-d]pyrimidin-6-ylcarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NBS / dimethylformamide / 16 h / 20 °C

2: 47 percent / P(2-furyl)3; Pd(dba)3 / 1-methyl-pyrrolidin-2-one / 18 h / 90 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; trifuran-2-yl-phosphane; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; 1: Bromination / 2: Substitution;
DOI:10.1016/S0960-894X(00)00442-X