diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate

Base Information

Chemical Name:diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate
CAS No.:852949-46-3
Molecular Formula:C₂₈H₃₃O₅P
Molecular Weight:480.541
Hs Code.:

Synonyms:diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate

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Chemical Property of diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate

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Technology Process of diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate

There total 13 articles about diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 683-08-9
Diethyl methylphosphonate

: 852949-45-2
methyl 4-(3'-benzyl-4'-methoxymethoxy-benzyl)-3,5-dimethyl-benzoate

: 852949-46-3
diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate

Guidance literature:: Diethyl methylphosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

methyl 4-(3'-benzyl-4'-methoxymethoxy-benzyl)-3,5-dimethyl-benzoate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2.5h;

Reference yield: 75.0%

: 683-08-9
Diethyl methylphosphonate

: 852949-44-1
4-(3'-benzyl-4'-methoxymethoxy-benzyl)-3,5-dimethyl-phenyl trifluoromethanesulfonate

: 852949-46-3
diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate

Guidance literature:: Diethyl methylphosphonate; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;

4-(3'-benzyl-4'-methoxymethoxy-benzyl)-3,5-dimethyl-phenyl trifluoromethanesulfonate; In tetrahydrofuran; hexanes; at -78 - 20 ℃; for 2.5h;

Reference yield:

: 852949-33-8
4-(3'-benzyl-4'-methoxymethoxy-benzyl)-3,5-dimethyl-phenol

: 852949-46-3
diethyl [3,5-dimethyl-4-[3'-benzyl-4'-hydroxy-benzyl]benzoyl]methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 2 h / 0 °C

2.1: bis(diphenyl-phosphino)propane; triethylamine / palladium diacetate / N,N-dimethyl-formamide / 16 h / 90 °C / 3102.97 Torr

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

3.2: 2.5 h / -78 - 20 °C

With dmap; n-butyllithium; bis(diphenyl-phosphino)propane; triethylamine; palladium diacetate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;