N-[(R)-(+)-1-phenylethyl]decanamide

Base Information

• Chemical Name: N-[(R)-(+)-1-phenylethyl]decanamide
• CAS No.: 933057-19-3
• Molecular Formula: C₁₈H₂₉NO
• Molecular Weight: 275.434
• Mol file: 933057-19-3.mol

Synonyms:N-[(R)-(+)-1-phenylethyl]decanamide

Chemical Property of N-[(R)-(+)-1-phenylethyl]decanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-[(R)-(+)-1-phenylethyl]decanamide

There total 2 articles about N-[(R)-(+)-1-phenylethyl]decanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-decanoic acid (334-48-5) + rac-methylbenzylamine (618-36-0) → N-[(R)-(+)-1-phenylethyl]decanamide (933057-19-3) + (S)-1-phenyl-ethylamine (2627-86-3)

Guidance literature:

With Candida antarctica lipase B; molecular sieve; In various solvent(s); at 45 ℃; for 24h;

DOI:10.1016/j.tetasy.2007.10.045

Reference yield:

Methyl decanoate (110-42-9) + rac-methylbenzylamine (618-36-0) → N-[(R)-(+)-1-phenylethyl]decanamide (933057-19-3)

Guidance literature:

With immobilized Candida antarctica Lipase B; hydrogen; Pd-BaSO₄; for 24h; under 75.006 Torr;

DOI:10.1039/b509747a

Reference yield: 98.0%

N-[(R)-(+)-1-phenylethyl]decanamide (933057-19-3) → (R)-1-phenyl-ethyl-amine (3886-69-9)

Guidance literature:

With Candida antarctica lipase B; In phosphate buffer; at 70 ℃; for 48h; pH=7;

DOI:10.1016/j.tetasy.2007.10.045

upstream raw materials:

Methyl decanoate

rac-methylbenzylamine

1-decanoic acid

Downstream raw materials:

(R)-1-phenyl-ethyl-amine

Refernces

• 1、 Torres-Gavilan,Escalante,Regla,Lopez-Munguia,Castillo. "'Easy-on, easy-off' resolution of chiral 1-phenylethylamine catalyzed by Candida antarctica lipase B". . p. 2621 - 2624. Retrieved 2008/04/05.