(2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone

Base Information

• Chemical Name: (2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone
• CAS No.: 174563-08-7
• Molecular Formula: C₁₀H₇F₅O₄S
• Molecular Weight: 318.221
• Mol file: 174563-08-7.mol

Synonyms:(2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone

Chemical Property of (2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone

There total 2 articles about (2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trifluoromethylsulfonic anhydride (358-23-6) + (2S)-2',4'-Difluoro-2-hydroxypropiophenone (126918-14-7) → (2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone (174563-08-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -30 ℃; for 0.5h;

DOI:10.1248/cpb.47.360

Reference yield:

→ (2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone (174563-08-7)

Guidance literature:

Reference yield: 34.0%

(2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone (174563-08-7) + 1-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone (181870-66-6) → 1-[(R)-2-(2,4-Difluoro-phenyl)-1-methyl-2-oxo-ethyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one (325988-93-0)

Guidance literature:

1-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

(2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at -20 ℃; for 0.5h;

DOI:10.1248/cpb.48.1935

upstream raw materials:

trifluoromethylsulfonic anhydride

(2S)-2',4'-Difluoro-2-hydroxypropiophenone

Downstream raw materials:

2-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-4-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-3(2H,4H)-1,2,4-triazolone

1-[(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2(1H,3H)-imidazolone

1-<(1R)-2-(2,4-difluorophenyl)-2-oxo-1-methylethyl>-3-<4-(2,2,3,3-tetrafluoropropoxy)phenyl>-2(1H,3H)-imidazolone

1-[(R)-2-(2,4-Difluoro-phenyl)-1-methyl-2-oxo-ethyl]-3-(4-tetrazol-1-yl-phenyl)-1,3-dihydro-imidazol-2-one