126918-14-7

Basic information

• Product Name: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (S)-
• CAS NO: 126918-14-7
• Molecular Formula: C9H8F2O2
• Molecular Weight: 186.158
• Mol File: 126918-14-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (S)-(126918-14-7)
• EPA Substance Registry System: 1-Propanone, 1-(2,4-difluorophenyl)-2-hydroxy-, (S)-(126918-14-7)

Safety Data

• Hazardous Substances Data: 126918-14-7(Hazardous Substances Data)

Upstream product

• 79-37-8 oxalyl dichloride 
• 535-17-1 (S)-2-acetoxypropionic acid 
• 372-18-9 1,3-Difluorobenzene 
• 7664-93-9 sulfuric acid 
• 85068-30-0 2',4'-difluoropropiophenone 
• 127001-03-0 (2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone 
• 126918-15-8 (S)-2-(p-toluenesulfonyloxy)-2',4'-difluoropropiophenone 
• 36394-75-9 (S)-2-acetoxypropanoyl chloride 

Downstream Products

• 126918-15-8 (S)-2-(p-toluenesulfonyloxy)-2',4'-difluoropropiophenone 
• 174563-08-7 (2S)-2',4'-difluoro-2-trifluoromethanesulfonyloxypropiophenone 
• 132563-81-6 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one 
• 126918-33-0 (1S)-1-<(2R)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 138373-69-0 (1S)-1-<(2S)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol 
• 135270-05-2 (2S,3S)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol 
• 126918-21-6 (2R,3R)-2-(2,4-difluorophenyl)-2-hydroxybutane-1,3-diyl dimethanesulfonate 
• 126918-21-6 Methanesulfonic acid (1S,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-3-methanesulfonyloxy-1-methyl-propyl ester 
• 126918-18-1 (2S,3R)-2-(2,4-difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(2-tetrahydropyranyloxy)-2-butanol 
• 126918-18-1 (2R,3S)-2-(2,4-Difluoro-phenyl)-1-(isopropoxy-dimethyl-silanyl)-3-(tetrahydro-pyran-2-yloxy)-butan-2-ol 
• 126917-48-4 (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol 
• 126918-19-2 (2R,3R)-2-(2,4-Difluorophenyl)-3-(2-tetrahydropyranyloxy)-1,2-butanediol 
• 126918-19-2 (2S,3S)-2-(2,4-Difluoro-phenyl)-3-(tetrahydro-pyran-2-yloxy)-butane-1,2-diol 
• 377078-82-5 [(1R)-1-[(2S)-2-(2,4-difluorophenyl)-2-oxiranyl]ethyl] benzoate 

Relevant articles and documents

Metal salts induced improved α-hydroxylation of ketones for the preparation of the key chiral intermediate of azole antifungals

The first example demonstrating the influence of metal salts for an improved synthesis of 2',4'-difluoro-(R)-2-hydroxypropiophenone, (2), a key intermediate for the preparation of azole antifungals such as Sch 42427 (1) in excellent enantiomeric excess and high chemical yield via the use of camphorsulfonyloxaziridines is described.

Total chiral synthesis of azole antifungals via α-hydroxylation of ketones

The use of camphorsulfonyl oxaziridines for the preparation of 2',4'-difluoro-(R)-2-hydroxypropiophenone, (2), a key intermediate for the synthesis of azole antifungals Sch 42427 and ER-30346 (1) in excellent enantiomeric excess and high chemical yield is described.

Triazole antifungals. III. Stereocontrolled synthesis of an optically active triazolylmethyloxirane precursor to antifungal oxazolidine derivatives

Stereocontrolled synthesis of an optically active triazolylmethyloxirane 2, an important intermediate for the preparation of antifungal oxazolidine compounds 1, was achieved by two methods using L-lactic acid as a starting material. The key intermediate ketone 6 used in the procedures also served for the synthesis of the enantiomer of 2 and the corresponding diastereomeric epoxide.