1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol

Base Information

Chemical Name:1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol
CAS No.:1203606-38-5
Molecular Formula:C₁₇H₂₀F₂N₄O
Molecular Weight:334.369
Hs Code.:

Synonyms:1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol

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Chemical Property of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol

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Technology Process of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol

There total 6 articles about 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1122509-85-6
2-(2', 4'-difluorophenyl)-1-propylamino-3-(1''', 2''', 4''') triazol-1'''-yl-propan-2-ol

: 106-96-7
propargyl bromide

: 1203606-38-5
1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 20 ℃; for 6h;
DOI:10.1039/c3ra41310a

Reference yield:

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1203606-38-5
1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 6 h / Reflux

2: potassium iodide; potassium carbonate / acetonitrile / 6 h / 20 °C

With potassium carbonate; triethylamine; potassium iodide; In ethanol; acetonitrile;
DOI:10.1039/c3ra41310a

Reference yield:

: 86404-63-9
1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone

: 1203606-38-5
1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-propyl-N-propargylamino)-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; cetyltrimethylammonim bromide / toluene / 3 h / 60 °C

1.2: 1 h / 0 °C

2.1: triethylamine / ethanol / 6 h / Reflux

3.1: potassium iodide; potassium carbonate / acetonitrile / 6 h / 20 °C

With cetyltrimethylammonim bromide; potassium carbonate; triethylamine; potassium iodide; sodium hydroxide; In ethanol; toluene; acetonitrile;
DOI:10.1039/c3ra41310a