2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate

Base Information

Chemical Name:2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate
CAS No.:1621064-60-5
Molecular Formula:C₂HF₃O₂*C₂₄H₃₃NO₃
Molecular Weight:497.555
Hs Code.:

Synonyms:2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate

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Chemical Property of 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate

Chemical Property:

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Technology Process of 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate

There total 10 articles about 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1621064-62-7
methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate

: 76-05-1
trifluoroacetic acid

: 1621064-60-5
2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate

Guidance literature:: methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate; With lithium hydroxide; In tetrahydrofuran; water; at 22 ℃;

trifluoroacetic acid;
DOI:10.1021/acsmedchemlett.0c00631

Reference yield:

: 1621064-59-2
2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid

: 76-05-1
trifluoroacetic acid

: 1621064-60-5
2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate

Guidance literature:: With HPLC;

Reference yield:

: 57404-87-2
3-methoxy-1-methylnaphthalene

: 1621064-60-5
2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron trichloride; tetra-(n-butyl)ammonium iodide / dichloromethane / 1 h / -78 - 0 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / Reflux

3.1: tin(IV) chloride / 1,2-dichloro-ethane / 1 h / 0 °C

3.2: 2 h / 0 - 20 °C

3.3: 1 h

4.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 20 °C

4.2: 3 h

5.1: water; lithium hydroxide / tetrahydrofuran / 22 °C

6.1: HPLC

With di-isopropyl azodicarboxylate; water; boron trichloride; tin(IV) chloride; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;