methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate

Base Information

Chemical Name:methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate
CAS No.:1621064-62-7
Molecular Formula:C₂₅H₃₅NO₃
Molecular Weight:397.558
Hs Code.:

Synonyms:methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate

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Chemical Property of methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate

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Technology Process of methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate

There total 7 articles about methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1621064-61-6
2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methyl-1-naphthaldehyde

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1621064-62-7
methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate

Guidance literature:: 2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methyl-1-naphthaldehyde; glycine ethyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; for 3h;

Reference yield:

: 26207-06-7
4-methylnaphthalen-2-ol

: 1621064-62-7
methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tert-butyl alcohol; butanone / 80 °C

2.1: tin(IV) chloride / 1,2-dichloro-ethane / 1 h / 0 °C

2.2: 2 h / 0 - 20 °C

2.3: 1 h

3.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 20 °C

3.2: 3 h

With tin(IV) chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; butanone; tert-butyl alcohol;

Reference yield:

: 57404-87-2
3-methoxy-1-methylnaphthalene

: 1621064-62-7
methyl 2-(((2-(((trans)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)amino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trichloride; tetra-(n-butyl)ammonium iodide / dichloromethane / 1 h / -78 - 0 °C / Inert atmosphere

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / Reflux

3.1: tin(IV) chloride / 1,2-dichloro-ethane / 1 h / 0 °C

3.2: 2 h / 0 - 20 °C

3.3: 1 h

4.1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 20 °C

4.2: 3 h

With di-isopropyl azodicarboxylate; boron trichloride; tin(IV) chloride; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; 1,2-dichloro-ethane; toluene;