(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid

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Chemical Name:(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid
CAS No.:1033881-21-8
Molecular Formula:C₂₅H₃₇N₅O₅
Molecular Weight:487.599
Hs Code.:

Synonyms:(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid

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Chemical Property of (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid

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Technology Process of (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid

There total 1 articles about (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033881-19-4
(1R,2S)-methyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylate

: 1033881-21-8
(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid

Guidance literature:: (1R,2S)-methyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylate; With sodium hydroxide; In ethanol; at 20 ℃; for 2h;

With hydrogenchloride; In ethanol;

Reference yield: 93.0%

: 402960-19-4
3-(S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide

: 1033881-21-8
(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid

: 1033881-23-0
N-((1S)-1-cyclohexyl-2-((2S)-1-((1S,2R)-2-(1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-ylcarbamoyl)cyclopentylamino)-3,3-dimethyl-1-oxobutan-2-ylamino)-2-oxoethyl)pyrazine-2-carboxamide

Guidance literature:: (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 0.5h;

3-(S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 3h;

Reference yield: 55.0%

: 3-amino-2-hydroxy-hexanoic acid {[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-amide

: 1033881-21-8
(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid

: C₄₁H₆₀N₈O₇

Guidance literature:: (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclopentanecarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 0.333333h;

3-amino-2-hydroxy-hexanoic acid {[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-amide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;