402960-19-4

Usage

Uses

Used in Pharmaceutical Industry:
(3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide is used as an active pharmaceutical ingredient for the development of antiviral drugs, specifically targeting the inhibition of the hepatitis C virus NS3·4A protease. Its unique structure allows it to interfere with the viral replication process, making it a promising candidate for the treatment of hepatitis C.
Used in Research and Development:
In addition to its pharmaceutical applications, (3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide can also be utilized in research and development for the study of viral proteases and their role in the replication of hepatitis C virus. (3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide can serve as a valuable tool in understanding the mechanisms of viral infection and the development of novel antiviral therapies.
Used in Drug Design and Synthesis:
(3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide's unique structure and properties make it a valuable starting point for the design and synthesis of new antiviral agents. Researchers can use (3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide as a template to create new molecules with improved potency, selectivity, and pharmacokinetic properties, ultimately leading to more effective treatments for hepatitis C and other viral infections.

Upstream product

• 6600-40-4 L-Norvaline 
• 145842-50-8 benzyl N-[(1S)-1-(hydroxymethyl)butyl]carbamate 
• 149357-16-4 (S)-2-benzyloxycarbonylaminopentanal 
• 928064-71-5 methyl (S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoate 
• 3249-68-1 ethyl butyroyl acetate 
• 67271-32-3 ethyl 2-chloro-3-oxohexanoate 
• 1166397-39-2 N-cyclopropyl-3-amino-2-hydroxyhexanamide hydrochloride 
• 402959-34-6 (S)-3-(benzyloxycarbonyl)amino-2-hydroxyhexanoylcyclopropylamide 

Downstream Products

• 954369-40-5 C₃₈H₅₉ClN₆O₈ 
• 954273-23-5 C₃₄H₅₃N₇O₆ 
• 615583-16-9 C₃₂H₅₅N₅O₅ 
• 945255-39-0 C₃₇H₅₇N₇O₆ 
• 945255-42-5 C₃₈H₅₈N₆O₆ 
• 945255-43-6 C₃₈H₅₈N₆O₆ 
• 945255-44-7 C₄₁H₅₉N₇O₆ 
• 945255-45-8 C₃₇H₅₇N₇O₈ 
• 945255-46-9 C₃₆H₅₇N₇O₆ 
• 945255-47-0 C₃₇H₅₉N₇O₆ 
• 945255-48-1 C₃₇H₅₈N₆O₆ 
• 945255-49-2 C₄₁H₅₉FN₆O₆ 
• 945255-50-5 C₃₈H₆₃N₅O₇ 
• 945255-51-6 C₃₇H₅₇N₅O₇ 

Relevant academic research and scientific papers

A pulls Swiss Wei intermediates for the synthesis of the new method

The invention discloses a method for preparing (3S)-3-amino-2-hydroxyl-N-cyclopropylhexanamide. The compound can be used as an important intermediate for preparing telaprevir. According to the invention, ethyl butyrylacetate is used as a starting raw material, and through steps of helogenation, substitution, amination, reduction, hydrolysis, deprotection, resolution and the like, (3S)-3-amino-2-hydroxyl-N-cyclopropylhexanamide is prepared. The method provided by the invention has advantages as follows: raw materials are cheap and easily available; reaction yield is high; and costs are high.

SYNTHESIS OF AN INTERMEDIATE OF AN ANTIVIRAL COMPOUND

Process for the preparation of a cyclopropylamide compound which is useful as a structural unit in a process for the preparation of a viral protease inhibitor.

Processes and intermediates

The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.

INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE

The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.