1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:880474-69-1
Molecular Formula:C₂₂H₂₀ClF₃I₂N₂O₄
Molecular Weight:722.669
Hs Code.:

Synonyms:1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 79-04-9
chloroacetyl chloride

: 180623-57-8
1-(4-Amino-3,5-diiodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 880474-69-1
1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With dmap; calcium carbonate; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2005.12.027

Reference yield: 93.0%

: 880474-69-1
1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 880474-71-5
1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With potassium carbonate; In methanol; water; for 7h;
DOI:10.1016/j.bmc.2005.12.027

Reference yield:

: 880474-69-1
1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1-[4-(α-chroroacetylamino)-3,5-diiodobenzyl]-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrobromide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / K₂CO₃ / methanol; H₂O / 7 h

2: 90 percent / BBr₃ / CH₂Cl₂ / cooling

With boron tribromide; potassium carbonate; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2005.12.027