1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea

Base Information

Chemical Name:1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea
CAS No.:1372971-93-1
Molecular Formula:C₂₄H₃₂F₃N₃OSSi
Molecular Weight:495.684
Hs Code.:

Synonyms:1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea

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Chemical Property of 1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea

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Technology Process of 1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea

There total 8 articles about 1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1372972-10-5
C₂₉H₄₀F₃N₃O₃SSi

: 1372971-93-1
1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea

Guidance literature:: C₂₉H₄₀F₃N₃O₃SSi; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 6h;

With ammonia; In water; pH=8;
DOI:10.1039/c2ob00049k

Reference yield:

: 1159114-52-9
tert-butyl (2S,4R)-4-azido-2-(((tert-butyldiphenylsilyl)oxy)methyl)pyrrolidine-1-carboxylate

: 1372971-93-1
1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / water

2.1: water; calcium carbonate / chloroform / 0 °C

3.1: triethylamine / dichloromethane / 5 h / 30 °C / Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C

4.2: pH 8

With water; triethylamine; triphenylphosphine; trifluoroacetic acid; calcium carbonate; In dichloromethane; chloroform; water;
DOI:10.1039/c2ob00049k

Reference yield:

: 317358-03-5
trans-4-amino-1-tert-butoxycarbonyl(2S)-(tert-butyldiphenylsilyloxy)methylpyrrolidine

: 1372971-93-1
1-((3R,5S)-5-((tert-butyldiphenylsilyloxy)methyl)pyrrolidin-3-yl)-3-(2,2,2-trifluoroethyl)thiourea

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; calcium carbonate / chloroform / 0 °C

2.1: triethylamine / dichloromethane / 5 h / 30 °C / Cooling with ice

3.1: trifluoroacetic acid / dichloromethane / 6 h / 0 °C

3.2: pH 8

With water; triethylamine; trifluoroacetic acid; calcium carbonate; In dichloromethane; chloroform;
DOI:10.1039/c2ob00049k