N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester
• CAS No.: 308321-88-2
• Molecular Formula: C₂₃H₂₉N₃O₇
• Molecular Weight: 459.499
• Mol file: 308321-88-2.mol

Synonyms:N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester

Chemical Property of N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester

There total 1 articles about N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-tert-butyloxycarbonyl-L-prolyl-L-phenylalanine (52071-65-5) → N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester (308321-88-2)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 46h;

DOI:10.1021/jm980645y

Reference yield:

pamidronate (40391-99-9) + N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester (308321-88-2) → L-prolyl-L-phenylalanylpamidronate + N-tert-butoxycarbonyl-L-prolyl-L-phenylalanylpamidronate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In water; isopropyl alcohol; for 48h;

DOI:10.1021/jm980645y

Reference yield:

4-amino-1-hydroxybutylidenebisphosphonic acid (66376-36-1) + N-tert-butoxycarbonyl-L-prolyl-L-phenylalanine N-hydroxysuccinimide ester (308321-88-2) → L-prolyl-L-phenylalanylalendronate + (S)-2-[(S)-1-(4-Hydroxy-4,4-bis-phosphono-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In water; isopropyl alcohol; for 48h;

DOI:10.1021/jm980645y

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-tert-butyloxycarbonyl-L-prolyl-L-phenylalanine