Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester
CAS No.:884525-59-1
Molecular Formula:C₂₄H₂₆N₄O₈
Molecular Weight:498.492
Hs Code.:

Synonyms:Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester

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Chemical Property of Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester

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Technology Process of Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester

There total 11 articles about Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 884525-57-9
Acetic acid (2R,3S,4R,5R,6R)-3-acetoxy-5-benzyloxycarbonylamino-6-phenoxy-2-(toluene-4-sulfonyloxymethyl)-tetrahydro-pyran-4-yl ester

: 884525-59-1
Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;
DOI:10.1021/ja056253f

Reference yield:

: 122210-05-3
1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranose

: 884525-59-1
Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / SnCl₄ / CH₂Cl₂ / 48 h / 20 °C

2: Zn; AcOH / tetrahydrofuran / 1.5 h / 20 °C

3: 1.13 g / aq. NaHCO₃ / CH₂Cl₂ / 1 h / 20 °C

4: Et₃N; MeOH / 12 h / 20 °C

5: pyridine / 1.5 h / 20 °C

6: 120 mg / pyridine / 1.5 h / 20 °C

7: 89 percent / NaN₃ / dimethylformamide / 2 h / 80 °C

With pyridine; methanol; sodium azide; tin(IV) chloride; sodium hydrogencarbonate; acetic acid; triethylamine; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja056253f

Reference yield:

: ((2R,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-phenoxy-tetrahydro-pyran-3-yl)-carbamic acid benzyl ester

: 884525-59-1
Acetic acid (2R,3R,4R,5R,6R)-3-acetoxy-2-azidomethyl-5-benzyloxycarbonylamino-6-phenoxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 1.5 h / 20 °C

2: 120 mg / pyridine / 1.5 h / 20 °C

3: 89 percent / NaN₃ / dimethylformamide / 2 h / 80 °C

With pyridine; sodium azide; In N,N-dimethyl-formamide;
DOI:10.1021/ja056253f