5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate

Base Information

Chemical Name:5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate
CAS No.:302800-06-2
Molecular Formula:C₂₄H₂₆N₂O₅
Molecular Weight:422.481
Hs Code.:

Synonyms:5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate

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Chemical Property of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate

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Technology Process of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate

There total 2 articles about 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 231947-12-9
4-benzyl-1-(3-propynyl)piperidine

: 302800-04-0
5-bromo-2-nitrophenyl ethyl carbonate

: 302800-06-2
5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dichloromethane; Heating;
DOI:10.1021/jm000023o

Reference yield:

: 27684-84-0
5-bromo-2-nitrophenol

: 302800-06-2
5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / K₂CO₃ / acetonitrile / 20 °C

2: 85 percent / Pd(PPh₃)2Cl₂; CuI; Et₃N / CH₂Cl₂ / Heating

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In dichloromethane; acetonitrile; 1: Acylation / 2: Arylation;
DOI:10.1021/jm000023o

Reference yield: 27.0%

: 530-62-1
1,1'-carbonyldiimidazole

: 302800-06-2
5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate

: 6-[3-(4-benzyl-piperidin-1-yl)-prop-1-ynyl]-3H-benzooxazol-2-one

Guidance literature:: 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-2-nitrophenyl ethyl carbonate; With hydrogenchloride; iron; In ethanol; for 0.5h; Heating;

With potassium carbonate; In acetonitrile; for 1h; Heating;

1,1'-carbonyldiimidazole; In acetonitrile; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jm000023o