27684-84-0

Basic information

• Product Name: PHENOL, 5-BROMO-2-NITRO-
• Synonyms: PHENOL, 5-BROMO-2-NITRO-;2-Nitro-5-bromophenol;3-Bromo-6-nitrophenol;5-Bromo-2-nitrophenol;5-bromo-2-ntrophenol;5-Bromo-2-nitrophenol 98%;4-Bromo-2-hydroxynitrobenzene;5-BroMo-2-nitrophenol, 97+%
• CAS NO: 27684-84-0
• Molecular Formula: C₆H₄BrNO₃
• Molecular Weight: 218
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 27684-84-0.mol
• Article Data: 22

Chemical Properties

• Melting Point: 40-420C
• Boiling Point: 264.6 °C at 760 mmHg
• Flash Point: 113.8 °C
• Appearance: Pale yellow/Crystalline Solid
• Density: 1.881 g/cm³
• Vapor Pressure: 0.00588mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: Room temperature.
• Solubility: Soluble in ethyl acetate and methanol.
• PKA: 6.08±0.13(Predicted)
• CAS DataBase Reference: PHENOL, 5-BROMO-2-NITRO-(CAS DataBase Reference)
• NIST Chemistry Reference: PHENOL, 5-BROMO-2-NITRO-(27684-84-0)
• EPA Substance Registry System: PHENOL, 5-BROMO-2-NITRO-(27684-84-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37-60
• RIDADR: 2811
• Hazardous Substances Data: 27684-84-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

It is used as pharmaceutical intermediate.

InChI:InChI=1/C6H4BrNO3/c7-4-1-2-5(8(10)11)6(9)3-4/h1-3,9H

Upstream product

• 591-20-8 3-Bromophenol 
• 586-78-7 para-nitrophenyl bromide 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 67-56-1 methanol 
• 860557-69-3 (5-bromo-2-nitro-phenyl)-arsonic acid 
• 610-38-8 4-bromo-1,2-dinitrobenzene 
• 7664-41-7 ammonia 

Downstream Products

• 858832-42-5 2,3,4-tribromo-6-nitro-phenol 
• 19046-86-7 3-bromo-2,4,6-trinitro-phenol 
• 116632-29-2 5-bromo-2,4-dinitro-phenol 
• 116632-22-5 3-bromo-2,6-dinitro-phenol 
• 1245708-19-3 (R)-methyl 2-(5-bromo-2-nitrophenoxy)propanoate 
• 1413929-84-6 C₁₄H₁₁BrClNO₂S 
• 1413930-02-5 C₁₄H₉BrClNO₂ 
• 1413929-91-5 C₁₄H₁₁BrClNO₂S 
• 1413930-07-0 C₁₄H₉BrClNO₂ 
• 321436-06-0 7-bromo-3,4-dihydro-2H-1,4-benzoxazin-3-one 
• 105679-22-9 7-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 1361110-64-6 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 1571111-33-5 N-phenyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide 
• 1571111-32-4 7-(3-amino-1H-indazol-4-yl)-N-phenyl-2H-benzo[b][1,4]oxazine-4(3H)-carboxamide 

Relevant articles and documents

Carbonylation as a novel method for the assembly of pyrazine based oligoamide alpha-helix mimetics

The design and synthesis of oligoamide α-helix peptidomimetics is reported. The oligoamide type systems are prepared in a modular fashion by coupling the monomers using palladium-catalyzed carbonylation chemistry. This enabled us to use substrates with a low nucleophilicity, leading to previously unreported pyrazine based oligoamide α-helix mimetics. The proof of principle is given by synthesizing a small set of compounds. Various end-capping groups were introduced and also a mixed multimer was successfully prepared.

Preparation and properties of clickable amino analogues of the duocarmycins: Factors that affect the efficiency of their fluorescent labelling of DNA

Herein we report the synthesis of three DNA-alkylating amino analogues of the duocarmycins that carry an alkyne functional group suitable for copper-catalysed click chemistry. The alkyne-containing substituents are connected via a side chain position whic

An ortho-nitro phenol synthetic method of compound

The invention relates to a synthesis method of o-nitrophenol compounds, solving the problems that production hazards are easily caused due to the release of a large deal of heat during the synthesis of o-nitrophenol and the severe environment pollution caused due to the generation of a large deal of waste gas and acid in the process in the prior art. The invention provides the synthesis method of the o-nitrophenol compounds, which comprises the steps: synthesizing 2-(phenoxy)pyridine from phenol compounds; and then sequentially adding 2-(phenoxy)pyridine and a catalyst, a nitrating reagent, an oxidant and an organic solvent into a sealed pressure container, heating and reacting for 10-50 hours in an oil bath of which the temperature is 80 DEG C-130 DEG C to obtain 2-(2-nitrophenyl)oxy pyridine; and finally treating to obtain o-nitrophenol. The synthesis method is simple, convenient and efficient.

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