2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Base Information

Chemical Name:2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide
CAS No.:1312607-86-5
Molecular Formula:C₁₉H₂₆N₂O₄
Molecular Weight:346.426
Hs Code.:

Synonyms:2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

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Chemical Property of 2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

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Technology Process of 2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

There total 4 articles about 2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1312607-70-7
2-(6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

: 75-36-5
acetyl chloride

: 1312607-86-5
2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Guidance literature:: With sodium carbonate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1312607-45-6
2-(4-benzyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

: 1312607-86-5
2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / acetic acid methyl ester / 5 h / 20 °C

2: sodium carbonate / dichloromethane / 20 °C

With hydrogen; sodium carbonate; palladium 10% on activated carbon; In dichloromethane; acetic acid methyl ester;

Reference yield:

: 1312608-01-7
4-benzyl-6,6-dimethylmorpholin-2-one

: 1312607-86-5
2-(4-acetyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; ethylbenzene / 1 h / -70 °C

1.2: 70 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 0.5 h / 20 °C

3.2: 20 °C

4.1: palladium 10% on activated carbon; hydrogen / acetic acid methyl ester / 5 h / 20 °C

5.1: sodium carbonate / 3 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetic acid methyl ester; ethylbenzene;
DOI:10.1021/jm501814x