4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide

Base Information

Chemical Name:4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide
CAS No.:112913-78-7
Molecular Formula:C₂₂H₂₉ClN₄O₄
Molecular Weight:448.95
Hs Code.:

Synonyms:4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide

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Chemical Property of 4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide

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Technology Process of 4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide

There total 7 articles about 4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 112913-80-1
4-Amino-5-chloro-2-methoxy-N-{4-[3-(4-nitro-phenoxy)-propyl]-morpholin-2-ylmethyl}-benzamide

: 112913-78-7
4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;
DOI:10.1248/cpb.40.652

Reference yield:

: 7206-70-4
4-amino-5-chloro-2-methoxybenzoic acid

: 112913-78-7
4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

2: 51 percent / H₂ / 5percent Pd/C / methanol / Ambient temperature

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1248/cpb.40.652

Reference yield:

: 13094-50-3
1-(3-bromopropoxy)-4-nitrobenzene

: 112913-78-7
4-amino-N-<<4-<3-(4-aminophenoxy)propyl>-2-morpholinyl>methyl>-5-chloro-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃, KI / butan-2-one / 17 h / Heating

2: 10percent NaOH / 20 h / Heating

3: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

4: 51 percent / H₂ / 5percent Pd/C / methanol / Ambient temperature

With sodium hydroxide; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; butanone;
DOI:10.1248/cpb.40.652