(4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride

Base Information

Chemical Name:(4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride
CAS No.:1313040-38-8
Molecular Formula:C₂₈H₃₅N₃O₅*ClH
Molecular Weight:530.064
Hs Code.:

Synonyms:(4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride

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Chemical Property of (4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride

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Technology Process of (4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride

There total 7 articles about (4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1313042-30-6
(4-(tert-butoxycarbonylamino-methyl)-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester

: 1313040-38-8
(4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 696-60-6
4-aminomethylphenol

: 1313040-38-8
(4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: bromine; hydrogen bromide / acetic acid / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: caesium carbonate / tetrahydrofuran / 20 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

5: hydrogen; acetic acid / platinum(IV) oxide / methanol / 3 h / 20 °C / 2585.81 - 3102.97 Torr

6: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

7: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; hydrogen bromide; hydrogen; bromine; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid;

Reference yield:

: 63491-89-4
4-(aminomethyl)-2-bromophenol hydrogenbromide salt

: 1313040-38-8
(4-aminomethyl-2-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-indole-3-carbonyl]-piperidin-4-yl}-phenoxy)-acetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: caesium carbonate / tetrahydrofuran / 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 80 °C

4: hydrogen; acetic acid / platinum(IV) oxide / methanol / 3 h / 20 °C / 2585.81 - 3102.97 Torr

5: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

6: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; hydrogen; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;