Technology Process of (3R,4R,5R)-5-{[((3R,4R,5R)-5-azidomethyl-3,4-di-O-benzyl-tetrahydrofuran-3-carbonyl)-amino]-methyl}-3,4-di-O-benzyl-tetrahydrofuran-3-carboxylic acid methyl ester
There total 4 articles about (3R,4R,5R)-5-{[((3R,4R,5R)-5-azidomethyl-3,4-di-O-benzyl-tetrahydrofuran-3-carbonyl)-amino]-methyl}-3,4-di-O-benzyl-tetrahydrofuran-3-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1007/s00726-011-0849-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.08 h / Molecular sieve; Inert atmosphere
1.2: 2.5 h / Molecular sieve; Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1007/s00726-011-0849-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.08 h / Molecular sieve; Inert atmosphere
1.2: 2.5 h / Molecular sieve; Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 3 h
3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1007/s00726-011-0849-7
