2-(3-indolyl)ethylphenyl ketone

Base Information

• Chemical Name: 2-(3-indolyl)ethylphenyl ketone
• CAS No.: 13993-17-4
• Molecular Formula: C17H15 N O
• Molecular Weight: 249.312
• Hs Code.: 2933990090
• Mol file: 13993-17-4.mol

Synonyms:Propiophenone,3-indol-3-yl- (8CI); 2-(3-Indolyl)ethyl phenyl ketone

Chemical Property of 2-(3-indolyl)ethylphenyl ketone

Chemical Property:

• Vapor Pressure: 5.14E-09mmHg at 25°C
• Boiling Point: 470.3°Cat760mmHg
• Flash Point: 241.5°C
• PSA: 32.86000
• Density: 1.183g/cm³
• LogP: 3.98340

Purity/Quality:

99% ^*data from raw suppliers

PROPAN-1-ONE, 3-(3-INDOLYL)-1-PHENYL- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-indolyl)ethylphenyl ketone

There total 11 articles about 2-(3-indolyl)ethylphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

indole (120-72-9) + Phenyl vinyl ketone (768-03-6,26742-84-7) → 3-(1H-indol-3-yl)-1-phenylpropan-1-one (13993-17-4)

Guidance literature:

With aluminium(III) triflate; at 80 ℃; for 0.833333h; Time; Wavelength; regioselective reaction;

DOI:10.1071/CH13254

Reference yield: 87.0%

indole (120-72-9) + 1-Phenyl-2-propyn-1-ol (4187-87-5) → 3-(1H-indol-3-yl)-1-phenylpropan-1-one (13993-17-4)

Guidance literature:

With C₂₄H₂₀N₂O₄Ru; trifluoroacetic acid; In toluene; at 170 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/anie.201801846

Reference yield: 86.0%

indole (120-72-9) + 1-phenyl-propan-1-one (93-55-0) → 3-(1H-indol-3-yl)-1-phenylpropan-1-one (13993-17-4)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N,N,N,N,-tetramethylethylenediamine; copper diacetate; In para-xylene; at 120 ℃; Reagent/catalyst; Inert atmosphere;

DOI:10.1039/c6ra19000f

upstream raw materials:

1-(1H-indol-3-yl)-N,N,N-trimethylmethanaminium methyl sulfate

indole

Phenyl vinyl ketone

3-(1H-indol-3-yl)-1-phenylprop-2-en-1-one

Downstream raw materials:

1-methyl-3-(3'-phenylbut-3'-enyl)indole

3-(1H-indol-3-yl)-1-phenylpropan-1-one oxime

ethyl 5-(1H-indol-3-yl)-3-phenylpent-2-enoate

ethyl 5-(1H-indol-3-yl)-3-phenylpent-2-enoate