[(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester

Base Information

• Chemical Name: [(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester
• CAS No.: 864169-21-1
• Molecular Formula: C₁₉H₂₅NO₈
• Molecular Weight: 395.409
• Mol file: 864169-21-1.mol

Synonyms:[(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester

Chemical Property of [(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of [(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester

There total 4 articles about [(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

[(2-ethoxycarbonylmethoxy-phenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester (864169-18-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → [(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester (864169-21-1)

Guidance literature:

With pyridine; trichlorophosphate; at 0 - 75 ℃;

DOI:10.1021/ol061297u

Reference yield:

2-amino-phenol (95-55-6) → [(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester (864169-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / NaI; diisopropylethylamine / acetonitrile / Heating

2: 65 percent / POCl₃; pyridine / 0 - 75 °C

With pyridine; N-ethyl-N,N-diisopropylamine; sodium iodide; trichlorophosphate; In acetonitrile;

DOI:10.1021/ol061297u

Reference yield:

trisodium o-aminophenol-N,N,O-triacetate → [(2-ethoxycarbonylmethoxy-4-formylphenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester (864169-21-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 15.8 g / H₂SO₄ / 72 h / Heating

2: 61 percent / pyridine; POCl₃ / 65 °C

With pyridine; sulfuric acid; trichlorophosphate; 1: Fischer esterification / 2: Vilsmeir-Haack formylation;

DOI:10.1055/s-2005-869900

upstream raw materials:

[(2-ethoxycarbonylmethoxy-phenyl)-ethoxycarbonylmethyl-amino]acetic acid ethyl ester

N,N-dimethyl-formamide

2-amino-phenol

Downstream raw materials:

C₃₇H₅₃BF₂N₆O₁₀

C₃₁H₃₈BF₂N₃O₇

C₄₈H₅₄N₄O₁₄