(S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

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Chemical Name:(S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid
CAS No.:1314607-37-8
Molecular Formula:C₃₅H₄₀F₃N₁₃O₁₀
Molecular Weight:859.779
Hs Code.:

(S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

Synonyms:(S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

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Chemical Property of (S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

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Technology Process of (S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

There total 8 articles about (S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314607-36-7
(S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

: 1314607-37-8
(S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

Guidance literature:: (S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate; With lithium hydroxide; at 20 ℃; Inert atmosphere;

With formic acid; In water; at 0 ℃; pH=4;

Reference yield:

: 69173-92-8
4-azido-1-nitro-2,3,5,6-tetrafluorobenzene

: 1314607-37-8
(S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetonitrile / 60 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

5.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 0 °C / Inert atmosphere

5.2: 42 h / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C / Inert atmosphere

6.2: 0 °C / pH 5

7.1: lithium hydroxide / 20 °C / Inert atmosphere

7.2: 0 °C / pH 4

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1314607-31-2
tert-butyl [3-(2-{2-[3-(3-azido-2,4,5-trifluoro-6-nitrophenylamino)propoxy]ethoxy}ethoxy)propyl]carbamate

: 1314607-37-8
(S)-18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 0 °C / Inert atmosphere

4.2: 42 h / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C / Inert atmosphere

5.2: 0 °C / pH 5

6.1: lithium hydroxide / 20 °C / Inert atmosphere

6.2: 0 °C / pH 4

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide;