(S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

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Chemical Name:(S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate
CAS No.:1314607-36-7
Molecular Formula:C₃₆H₄₂F₃N₁₃O₁₀
Molecular Weight:873.806
Hs Code.:

(S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

Synonyms:(S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

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Chemical Property of (S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

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Technology Process of (S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

There total 7 articles about (S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1314607-35-6
(S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

: 1314607-36-7
(S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

Guidance literature:: (S)-Methyl 1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-18-(4-(N-((2-(((dimethylamino)methylene)amino)-4-oxo-3,4-dihydropteridin-6-yl)methyl)formamido)benzamido)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate; With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 1h; Inert atmosphere;

In 1,4-dioxane; water; at 0 ℃; pH=5;

Reference yield:

: 69173-92-8
4-azido-1-nitro-2,3,5,6-tetrafluorobenzene

: 1314607-36-7
(S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 60 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

5.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 0 °C / Inert atmosphere

5.2: 42 h / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C / Inert atmosphere

6.2: 0 °C / pH 5

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 194920-62-2
tert-butyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate

: 1314607-36-7
(S)-methyl 18-(4-(((2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzamido)-1-((3-azido-2,4,5-trifluoro-6-nitrophenyl)amino)-15-oxo-4,7,10-trioxa-14-azanonadecan-19-oate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 60 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; water / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

5.1: 4-methyl-morpholine / N,N-dimethyl-formamide / 15 h / 0 °C / Inert atmosphere

5.2: 42 h / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C / Inert atmosphere

6.2: 0 °C / pH 5

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;