(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester
CAS No.:192211-85-1
Molecular Formula:C₁₄H₁₉NO₄
Molecular Weight:265.309
Hs Code.:

Synonyms:(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

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Chemical Property of (S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

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Technology Process of (S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

There total 2 articles about (S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 108-24-7
acetic anhydride

: 162631-41-6
(S)-3-(4-Methoxy-phenyl)-2-methylamino-propionic acid methyl ester

: 192211-85-1
(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 12h;
DOI:10.1021/jo9623696

Reference yield:

: 192211-84-0
(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

: 192211-85-1
(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / H₂ / Pd/C / methanol; ethyl acetate / 3 h / 2068.6 Torr

2: 87 percent / Et₃N / CH₂Cl₂ / 12 h

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo9623696

Reference yield:

: 192211-85-1
(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

: 192211-69-1
(2S,3R)-3-[(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionyloxy]-2-tert-butoxycarbonylamino-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / aq. LiOH / tetrahydrofuran / 6 h

2: 82 percent / Et₃N, DMAP, isopropenyl chloroformate / CH₂Cl₂ / 1 h / 0 °C

3: 91 percent / H₂ / Pd/C / methanol; ethyl acetate / 3 h / 2068.6 Torr

With dmap; lithium hydroxide; Isopropenyl chloroformate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo9623696