(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester
• CAS No.: 192211-84-0
• Molecular Formula: C₂₀H₂₃NO₅
• Molecular Weight: 357.406
• Mol file: 192211-84-0.mol

Synonyms:(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

Chemical Property of (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

There total 2 articles about (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Z-L-Tyr-OH (1164-16-5) + dimethyl sulfate (77-78-1) → (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester (192211-84-0)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide;

DOI:10.1080/00397911.2011.618284

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester (192211-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / chloroform; water

2: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate

With tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate; potassium hydroxide; In chloroform; water;

DOI:10.1080/00397911.2011.618284

Reference yield: 91.0%

(S)-2-(Benzyloxycarbonyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester (192211-84-0) → (S)-3-(4-Methoxy-phenyl)-2-methylamino-propionic acid methyl ester (162631-41-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; for 3h;

DOI:10.1080/00397919708004186

upstream raw materials:

Z-L-Tyr-OH

dimethyl sulfate

benzyl chloroformate

Downstream raw materials:

(2S)-3-[4-(methyloxy)phenyl]-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)propanoic acid

(S)-3-(4-Methoxy-phenyl)-2-methylamino-propionic acid methyl ester

(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

(S)-2-(Acetyl-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid