3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester

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Chemical Name:3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester
CAS No.:1276125-33-7
Molecular Formula:C₂₂H₃₃N₅O₃Si
Molecular Weight:443.621
Hs Code.:

3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester

Synonyms:3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester

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Chemical Property of 3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester

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Technology Process of 3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester

There total 5 articles about 3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1276125-32-6
C₁₆H₁₉N₅O₂

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1276125-33-7
3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester

Guidance literature:: C₁₆H₁₉N₅O₂; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 44981-94-4
N-cyanoethyl glycine ethyl ester

: 1276125-33-7
3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3 h / Inert atmosphere; Cooling with ice bath

2.1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: pH 3 / Ice water

3.1: hydrazine dihydrochloride / ethanol / 2.5 h / 60 °C

4.1: toluene / 20 - 60 °C

5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0 °C

5.2: 20 °C

With hydrazine dihydrochloride; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 16172-31-9
N-benzyloxycarbonyl-N-(2-cyano-ethyl)-glycine ethyl ester

: 1276125-33-7
3-(dimethylamino-methyleneamino)-1-(2-trimethylsilanyl-ethoxymethyl)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: pH 3 / Ice water

2.1: hydrazine dihydrochloride / ethanol / 2.5 h / 60 °C

3.1: toluene / 20 - 60 °C

4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0 °C

4.2: 20 °C

With hydrazine dihydrochloride; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; mineral oil;