Technology Process of (E)-2-(3,4-dimethoxystyryl)-5-methyloxazole-4-carbaldehyde
There total 5 articles about (E)-2-(3,4-dimethoxystyryl)-5-methyloxazole-4-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2-(3,4-dimethoxystyryl)-5-methyloxazol-4-yl)methanol;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
Inert atmosphere;
With
triethylamine;
In
dichloromethane;
at -78 - 0 ℃;
Inert atmosphere;
DOI:10.1039/b810855b
- Guidance literature:
-
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane; water;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/anie.201304492
- Guidance literature:
-
Multi-step reaction with 4 steps
1: diisobutylaluminium hydride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere
2: sodium hydride; sodium iodide / tetrahydrofuran; mineral oil / 7 h / Inert atmosphere
3: potassium phosphate; bis(1,5-cyclooctadiene)nickel (0); 1,2-bis-(dicyclohexylphosphino)ethane / 1,4-dioxane / 24 h / 170 °C / Inert atmosphere; Glovebox
4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 2 h / 0 - 20 °C / Inert atmosphere
With
bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; sodium hydride; diisobutylaluminium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; 1,2-bis-(dicyclohexylphosphino)ethane;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; mineral oil;
DOI:10.1002/anie.201304492