41172-57-0

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5-methyl-4-oxazolecarboxylate is used as a reagent for the synthesis of various substituted oxazolyl-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles. These compounds are essential in the development of new pharmaceuticals, particularly those with potential applications in the treatment of various diseases and conditions.
Used in Organic Chemistry Research:
In the field of organic chemistry, Methyl 5-methyl-4-oxazolecarboxylate is used as a reagent in the synthesis of complex molecular structures, such as Muscoride A. Methyl 5-methyl-4-oxazolecarboxylate has been studied for its potential biological activities and may hold promise for future drug development.
Overall, Methyl 5-methyl-4-oxazolecarboxylate plays a crucial role in the synthesis of various heterocyclic compounds, which are essential in the pharmaceutical industry and organic chemistry research. Its versatility as a reagent allows for the creation of a wide range of molecular structures with potential applications in drug development and other areas of scientific inquiry.

InChI:InChI=1/C6H7NO3/c1-4-5(6(8)9-2)7-3-10-4/h3H,1-2H3

Upstream product

• 706822-01-7 N-(1-methoxycarbonyl-2-oxopropyl)formamide 
• 24762-04-7 2-Diazo-3-oxo-butyric acid methyl ester 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 1096163-95-9 (E)-methyl 2-(3,4-dimethoxystyryl)-5-methyloxazole-4-carboxylate 
• 1638125-53-7 C₁₃H₁₁NO₄ 
• 874821-67-7 4-hydroxymethyl-5-methyloxazole 
• 1096163-97-1 (E)-2-(3,4-dimethoxystyryl)-5-methyloxazole-4-carbaldehyde 
• 170959-44-1 1-(5-methyloxazole-4-carboxyl)-4-phenylthiosemicarbazide 
• 170959-52-1 3-(4-methyl-4-oxazoyl)-4-phenyl-5-methylthio-4H-1,2,4-triazole 
• 170959-35-0 5-(5-methyl-4-oxazoyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 103879-58-9 5-methyloxazole-4-carboxylic acid 
• 170959-36-1 5-methyloxazole-4-carboxylic acid hydrazide 
• 68277-01-0 2-amino-3-oxo-butyric acid methyl ester 

Relevant academic research and scientific papers

Method of coupling, and the coupling method using the aromatic group-substituted heterocyclic compound

Provided is an easy method (coupling method) capable of easily synthesizing a compound group in which aromatic molecules and aromatic molecules are coupled, a compound group in which aromatic molecules and alkene molecules are coupled, and the like without producing halogen waste and without the need to use scarce and expensive palladium. A compound (A) shown by general formula (A): Ar-H and a compound (B1) shown by general formula (B1): RaOCO-Ar', a compound (B2) shown by general formula (B2): RbCH=C(Ar")2, or a compound (B3) shown by general formula (B3): RcOCOCH=C(Ar")2 are reacted in the presence of a nickel compound.

Nickel-catalyzed decarboxylative acylation of heteroarenes by sp 2 C-H functionalization

Nickel-catalyzed ligand-free decarboxylative cross-coupling of azole derivatives with α-oxoglyoxylic acids has been developed. This work represents the first example of decarboxylative cross-coupling reactions, in a C-H bond functionalization manner, thro

Nickel-catalyzed decarboxylative arylation of heteroarenes through sp2 C-H functionalization

The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel-catalyzed sp2 C-H functionalization process was developed. This process provides the first examples of decarboxylative cross-coupling reactions with aroma

C-H alkenylation of azoles with enols and esters by nickel catalysis

Rather u(Ni)que: Two new C-H alkenylation reactions, that is C-H/Ci￡O alkenylation and decarbonylative C-H alkenylation, of azoles are uniquely catalyzed by Ni/dcype. These azole alkenylation reactions are successfully applied to the convergent formal synthesis of siphonazoleB.

Decarbonylative C-H coupling of azoles and aryl esters: Unprecedented nickel catalysis and application to the synthesis of muscoride A

A nickel-catalyzed decarbonylative C-H biaryl coupling of azoles and aryl esters is described. The newly developed catalytic system does not require the use of expensive metal catalysts or silver- or copper-based stoichiometric oxidants. We have successfully applied this new C-H arylation reaction to a convergent formal synthesis of muscoride A.

Nickel-catalyzed C-H/C-O coupling of azoles with phenol derivatives

The first nickel-catalyzed C-H bond arylation of azoles with phenol derivatives is described. The new Ni(cod)2/dcype catalytic system is active for the coupling of various phenol derivatives such as esters, carbamates, carbonates, sulfamates, triflates, tosylates, and mesylates. With this C-H/C-O biaryl coupling, we synthesized a series of privileged 2-arylazoles, including biologically active alkaloids. Moreover, we demonstrated the utility of the present reaction for functionalizing estrone and quinine.

Programmable oligomers for minor groove DNA recognition

The four Watson-Crick base pairs of DNA can be distinguished in the minor groove by pairing side-by-side three five-membered aromatic carboxamides, imidazole (Im), pyrrole (Py), and hydroxypyrrole (Hp), four different ways. On the basis of the paradigm of

N-H Insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles

Dirhodium(II) carboxylate catalysed reaction of diazocarbonyl compounds 2 in the presence of primary amides 1 results in the formation of α-acylaminoketones 3 (12 examples) by N-H insertion reaction of the intermediate rhodium carbene. The 1,4-dicarbonyl

Note on the Preparation of 5-Methyloxazole

The title compound 4 was synthesized starting from methyl isocyanoacetate (1).