(2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester

Base Information

Chemical Name:(2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester
CAS No.:177036-71-4
Molecular Formula:C₂₂H₂₂O₅
Molecular Weight:366.414
Hs Code.:

Synonyms:(2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester

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Chemical Property of (2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester

Chemical Property:

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Technology Process of (2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester

There total 2 articles about (2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177036-68-9
(2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 6-methyl ester

: 177036-71-4
(2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / dimethylformamide; CH₂Cl₂ / 1 h / Heating

2: NEt₃ / tetrahydrofuran / Ambient temperature

With oxalyl dichloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja9602509

Reference yield:

: 2325-10-2
(S,S)-hydrobenzoin

: (2E,4E)-5-Chlorocarbonyl-hexa-2,4-dienoic acid methyl ester

: 177036-71-4
(2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; Yield given; Ambient temperature;
DOI:10.1021/ja9602509

Reference yield:

: 177036-71-4
(2E,4E)-2-Methyl-hexa-2,4-dienedioic acid 1-((1S,2S)-2-hydroxy-1,2-diphenyl-ethyl) ester 6-methyl ester

: 382-45-6
adrenosterone

Guidance literature:: Multi-step reaction with 8 steps

1: DMAP / tetrahydrofuran / 0 - 20 °C

2: toluene / 18 h / 200 °C

3: K₂CO₃ / 14 h / Ambient temperature

4: 76 percent / Mg, MeOH / 2.5 h / Heating

5: t-BuOK / benzene / 5 h / Heating

6: AcOH, aq. HCl / 1 h / Heating

7: 5percent aq. NaOH / methanol / 1 h / Heating

8: aq. Hg(ClO₄)2 / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; methanol; dmap; sodium hydroxide; mercury(II) perchlorate; potassium tert-butylate; potassium carbonate; magnesium; acetic acid; In tetrahydrofuran; methanol; toluene; benzene;
DOI:10.1021/ja9602509