382-45-6Relevant articles and documents
Reichstein
, (1937)
Reductive Alkylation of Enediones. 2. Synthesis of Corticosteroids
Stork, Gilbert,Logusch, E. W.
, p. 1219 - 1220 (1980)
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A straightforward chemical synthesis of 17-ketosteroids by cleavage of the C-17-dihydroxy acetone side chain in corticosteroids
Le Pera, Adolfo,Leggio, Antonella,Siciliano, Carlo,Di Gioia, Maria L.,Napoli, Anna,Sindona, Giovanni,Liguori, Angelo
, p. 139 - 142 (2003)
A facile and convenient approach to 17-ketosteroids is described. Treatment of steroids containing the C-17-dihydroxy acetone side chain with an excess of sodium methoxide in dry 1,4-dioxane under reflux, affords high yields of the corresponding 17-ketosteroids that are recovered as pure products, without the need of further purification.
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Reichstein
, p. 978,987 (1937)
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Iodine-promoted cleavage of the C-17-dihydroxyacetone side chain of corticosteroids in aqueous ammonia water
Sun, Liang,Geng, Xin,Liu, Lanhai,Jiang, Chenggang,Wang, Cunde
, p. 22 - 23 (2009)
A convenient approach to 17-ketosteroids by the iodine-promoted cleavage of the C-17-dihydroxy acetone side chain of corticosteroids is described. Treatment of steroids containing the C-17-dihydroxyacetone side chain with iodine and an excess of aqueous ammonia in acetonitrile at 50°ffords high yields of the corresponding 17-ketosteroids.
HYDROXYSTEROID COMPOUNDS, THEIR INTERMEDIATES, PROCESS OF PREPARATION, COMPOSITION AND USES THEREOF
-
, (2016/02/09)
The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds.