(S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Base Information

Chemical Name:(S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid
CAS No.:81578-30-5
Molecular Formula:C₂₁H₃₀N₂O₅S₂
Molecular Weight:454.612
Hs Code.:

Synonyms:(S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

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Chemical Property of (S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

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Technology Process of (S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

There total 10 articles about (S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 81578-22-5
(S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

: 81578-30-5
(S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; Ambient temperature;

Reference yield:

: 81578-22-5
Dmoc-Phe-Leu-OtBu

: 81578-30-5
Dmoc-Phe-Leu-OH

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃;

Reference yield:

: 20461-89-6
1,3-dithiane-2-carboxylic acid

: 81578-30-5
(S)-2-[(S)-2-([1,3]Dithian-2-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / LiAlH₄ / diethyl ether / 4 h / 0 °C

2: 63 percent / NEt₃ / CH₂Cl₂ / 12 h / Ambient temperature

3: 3PhCH₂N>⁺OH^- / 1) MeOH, 2) DMF, 12 h, r.t.

4: 100 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / Ambient temperature

5: 77 percent / CF₃COOH / CH₂Cl₂ / Ambient temperature

With 1-hydroxy-pyrrolidine-2,5-dione; lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In diethyl ether; dichloromethane;