1,3-Dithian-2-ylmethoxycarbonyl-L-phenylalanyl-L-leucyl-L-alanyl-L-leucin-tert-butylester

Base Information

Chemical Name:1,3-Dithian-2-ylmethoxycarbonyl-L-phenylalanyl-L-leucyl-L-alanyl-L-leucin-tert-butylester
CAS No.:81578-37-2
Molecular Formula:C₃₄H₅₄N₄O₇S₂
Molecular Weight:694.957
Hs Code.:

Synonyms:

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Chemical Property of 1,3-Dithian-2-ylmethoxycarbonyl-L-phenylalanyl-L-leucyl-L-alanyl-L-leucin-tert-butylester

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Technology Process of 1,3-Dithian-2-ylmethoxycarbonyl-L-phenylalanyl-L-leucyl-L-alanyl-L-leucin-tert-butylester

There total 8 articles about 1,3-Dithian-2-ylmethoxycarbonyl-L-phenylalanyl-L-leucyl-L-alanyl-L-leucin-tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20461-89-6
1,3-dithiane-2-carboxylic acid

: 81578-37-2
1,3-Dithian-2-ylmethoxycarbonyl-L-phenylalanyl-L-leucyl-L-alanyl-L-leucin-tert-butylester

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / LiAlH₄ / diethyl ether / 4 h / 0 °C

2: 63 percent / NEt₃ / CH₂Cl₂ / 12 h / Ambient temperature

3: 3PhCH₂N>⁺OH^- / 1) MeOH, 2) DMF, 12 h, r.t.

4: 100 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / Ambient temperature

5: 77 percent / CF₃COOH / CH₂Cl₂ / Ambient temperature

6: 1) ClCO₂Et/NEt₃ / 1) CH₂Cl₂, -15 deg C to r.t., 1 h, 2) CH₂Cl₂, -15 deg C to r.t., 12 h

With 1-hydroxy-pyrrolidine-2,5-dione; lithium aluminium tetrahydride; chloroformic acid ethyl ester; N-benzyl-trimethylammonium hydroxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In diethyl ether; dichloromethane;

Reference yield:

: 37721-88-3
2-(hydroxymethyl)-1,3-dithiane

: 81578-37-2
1,3-Dithian-2-ylmethoxycarbonyl-L-phenylalanyl-L-leucyl-L-alanyl-L-leucin-tert-butylester

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / NEt₃ / CH₂Cl₂ / 12 h / Ambient temperature

2: 3PhCH₂N>⁺OH^- / 1) MeOH, 2) DMF, 12 h, r.t.

3: 100 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / Ambient temperature

4: 77 percent / CF₃COOH / CH₂Cl₂ / Ambient temperature

5: 1) ClCO₂Et/NEt₃ / 1) CH₂Cl₂, -15 deg C to r.t., 1 h, 2) CH₂Cl₂, -15 deg C to r.t., 12 h

With 1-hydroxy-pyrrolidine-2,5-dione; chloroformic acid ethyl ester; N-benzyl-trimethylammonium hydroxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 34906-12-2
2-formyl-1,3-dithiane

: 81578-37-2
1,3-Dithian-2-ylmethoxycarbonyl-L-phenylalanyl-L-leucyl-L-alanyl-L-leucin-tert-butylester

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / aq. MeOH, NaBH₄ / 0 °C

2: 63 percent / NEt₃ / CH₂Cl₂ / 12 h / Ambient temperature

3: 3PhCH₂N>⁺OH^- / 1) MeOH, 2) DMF, 12 h, r.t.

4: 100 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / Ambient temperature

5: 77 percent / CF₃COOH / CH₂Cl₂ / Ambient temperature

6: 1) ClCO₂Et/NEt₃ / 1) CH₂Cl₂, -15 deg C to r.t., 1 h, 2) CH₂Cl₂, -15 deg C to r.t., 12 h

With methanol; sodium tetrahydroborate; 1-hydroxy-pyrrolidine-2,5-dione; chloroformic acid ethyl ester; N-benzyl-trimethylammonium hydroxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;