(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

Base Information

Chemical Name:(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide
CAS No.:1326281-02-0
Molecular Formula:C₁₅H₁₉ClF₂N₄O
Molecular Weight:344.792
Hs Code.:

Synonyms:(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

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Chemical Property of (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

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Technology Process of (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

There total 2 articles about (trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 288315-03-7
3,3-difluoroazetidine hydrochloride

: 1326280-45-8
N-((3-chloropyrazin-2-yl)methyl)-4-oxocyclohexane-1-carboxamide

: 1326281-02-0
(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

: 1352390-49-8
(cis)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

Guidance literature:: 3,3-difluoroazetidine hydrochloride; In methanol; dichloromethane; for 0.333333h;

N-((3-chloropyrazin-2-yl)methyl)-4-oxocyclohexane-1-carboxamide; With methanol; sodium cyanoborohydride; acetic acid; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 874-61-3
4-oxocyclohexanecarboxylic acid

: 1326281-02-0
(trans)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

: 1352390-49-8
(cis)-N-((3-chloropyrazin-2-yl)methyl)-4-(3,3-difluoroazetidin-1-yl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; HATU / dichloromethane / 16 h / 20 °C

2.1: Si-Carbonate / dichloromethane; methanol / 0.33 h

2.2: 72 h / 20 °C

With triethylamine; HATU; In methanol; dichloromethane;