1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid

Base Information

Chemical Name:1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid
CAS No.:268544-90-7
Molecular Formula:C₁₄H₉Cl₂F₃N₂O₄
Molecular Weight:397.138
Hs Code.:

Synonyms:1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid

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Chemical Property of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid

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Technology Process of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid

There total 3 articles about 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 268544-85-0
ethyl 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate

: 268544-90-7
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid

Guidance literature:: With potassium hydroxide; In methanol; at 0 ℃; for 24h;
DOI:10.1002/jhet.5570370129

Reference yield:

: 86398-94-9
2,6-dichloro-4-(trifluoromethyl)phenyl hydrazine

: 268544-90-7
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / CH₂Cl₂ / 0 °C

2: 75 percent / 1M aq. KOH / methanol / 24 h / 0 °C

With potassium hydroxide; In methanol; dichloromethane; 1: cyclocondensation / 2: Hydrolysis;
DOI:10.1002/jhet.5570370129

Reference yield:

: 127107-00-0
ethyl 2-amino-3-methoxycarbonyl-4-oxo-2-pentanoate

: 268544-90-7
1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / CH₂Cl₂ / 0 °C

2: 75 percent / 1M aq. KOH / methanol / 24 h / 0 °C

With potassium hydroxide; In methanol; dichloromethane; 1: cyclocondensation / 2: Hydrolysis;
DOI:10.1002/jhet.5570370129