1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone

Base Information

Chemical Name:1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone
CAS No.:348620-35-9
Molecular Formula:C₂₄H₂₅NO₅
Molecular Weight:407.466
Hs Code.:

Synonyms:1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone

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Chemical Property of 1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone

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Technology Process of 1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone

There total 7 articles about 1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 619-44-3
methyl 4-iodobenzoate

: 1-phenethyl-3-methoxycarbonyl-4-vinyl-2-pyrrolidinone

: 348620-35-9
1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone

Guidance literature:: With copper(l) iodide; tris-(o-tolyl)phosphine; palladium diacetate; In N,N-dimethyl-formamide; at 70 ℃; for 18h;
DOI:10.1021/jo001580l

Reference yield:

: 26011-68-7
methyl N-(2-phenylethyl)carbamate

: 348620-35-9
1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C

2: 76 percent / KOH; N₂H₄*H₂O / ethane-1,2-diol / 110 °C

3: 83 percent / Et₃N; DMAP / ethyl acetate / 0 - 20 °C

4: 87 percent / Mn(OAc)3*2H₂O; Cu(OAc)2*H₂O / acetic acid / 20 °C

5: 69 percent / CuI; (o-tolyl)3P / Pd(OAc)2 / dimethylformamide / 18 h / 70 °C

With dmap; potassium hydroxide; copper(l) iodide; copper diacetate; manganese triacetate; tetra-(n-butyl)ammonium iodide; sodium hydride; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; ethylene glycol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; 5: Heck reaction;
DOI:10.1021/jo001580l

Reference yield:

: 64-04-0
phenethylamine

: 348620-35-9
1-phenethyl-3-methoxycarbonyl-4-(4'-methoxycarbonylstyryl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / K₂CO₃ / acetone / Heating

2: 88 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 20 °C

3: 76 percent / KOH; N₂H₄*H₂O / ethane-1,2-diol / 110 °C

4: 83 percent / Et₃N; DMAP / ethyl acetate / 0 - 20 °C

5: 87 percent / Mn(OAc)3*2H₂O; Cu(OAc)2*H₂O / acetic acid / 20 °C

6: 69 percent / CuI; (o-tolyl)3P / Pd(OAc)2 / dimethylformamide / 18 h / 70 °C

With dmap; potassium hydroxide; copper(l) iodide; copper diacetate; manganese triacetate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; ethylene glycol; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone; 6: Heck reaction;
DOI:10.1021/jo001580l