(1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol

Base Information

Chemical Name:(1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol
CAS No.:475161-07-0
Molecular Formula:C₂₇H₃₂O₃Si
Molecular Weight:432.635
Hs Code.:

Synonyms:(1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol

Chemical Property:

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Technology Process of (1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol

There total 9 articles about (1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (+/-)-acetic acid 1-[4-(tert-butyldiphenylsilanoxymethyl)phenyl]-2-oxiranyl-ethyl ester

: 475161-07-0
(1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol

Guidance literature:: With Pseudomonas cepacia lipase; In hexane; acetone; butan-1-ol; for 35h;
DOI:10.1021/ol016915f

Reference yield:

: 589-29-7
p-xylylene glycol

: 475161-07-0
(1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 87 percent / imidazole / dimethylformamide / 24 h

2.1: 74 percent / N-methylmorpholine oxide / RuCl₂(PPh₃)3 / acetone / 0.42 h

3.1: 68 percent / LiCl; KI; Ga / tetrahydrofuran / 14 h / 60 °C

4.1: 65 percent / DIBAL / diethyl ether / 3 h / 38 °C

5.1: 50 percent / vanadyl acetylacetonate; TBHP / CH₂Cl₂; 1,2-dichloro-ethane / 24 h

6.1: t-BuOK / tetrahydrofuran / 0.3 h / 0 °C

6.2: 67 percent / aq. NaHSO₄ / tetrahydrofuran / 4 h / 20 °C

7.1: 91 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 0.25 h / 0 °C

8.1: 90 percent / Pseudomonas cepacia Lipase / acetone; butan-1-ol; hexane / 35 h

With 1H-imidazole; tert.-butylhydroperoxide; dmap; Pseudomonas cepacia lipase; vanadyl acetylacetonate; potassium tert-butylate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; (3S,3aS,4S,4aS,6S,8aR,8bR,11S)-6,11-dihydroxy-3-methyl-12-methylene-2-oxo-4a,6-ethano-3,8b-prop-1-enoperhydroindeno[1,2-b]furan-4-carboxylic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; lithium chloride; tris(triphenylphosphine)ruthenium(II) chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; butan-1-ol;
DOI:10.1021/ol016915f

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 475161-07-0
(1R)-1-[4-(tert-butyldiphenylsilanyloxymethyl)phenyl]-2-oxiranyl-ethanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 87 percent / imidazole / dimethylformamide / 24 h

2.1: 74 percent / N-methylmorpholine oxide / RuCl₂(PPh₃)3 / acetone / 0.42 h

3.1: 68 percent / LiCl; KI; Ga / tetrahydrofuran / 14 h / 60 °C

4.1: 65 percent / DIBAL / diethyl ether / 3 h / 38 °C

5.1: 50 percent / vanadyl acetylacetonate; TBHP / CH₂Cl₂; 1,2-dichloro-ethane / 24 h

6.1: t-BuOK / tetrahydrofuran / 0.3 h / 0 °C

6.2: 67 percent / aq. NaHSO₄ / tetrahydrofuran / 4 h / 20 °C

7.1: 91 percent / i-Pr₂NEt; DMAP / CH₂Cl₂ / 0.25 h / 0 °C

8.1: 90 percent / Pseudomonas cepacia Lipase / acetone; butan-1-ol; hexane / 35 h

With 1H-imidazole; tert.-butylhydroperoxide; dmap; Pseudomonas cepacia lipase; vanadyl acetylacetonate; potassium tert-butylate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; (3S,3aS,4S,4aS,6S,8aR,8bR,11S)-6,11-dihydroxy-3-methyl-12-methylene-2-oxo-4a,6-ethano-3,8b-prop-1-enoperhydroindeno[1,2-b]furan-4-carboxylic acid; N-ethyl-N,N-diisopropylamine; potassium iodide; lithium chloride; tris(triphenylphosphine)ruthenium(II) chloride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; butan-1-ol;
DOI:10.1021/ol016915f